Discovery and Development of a Immunosuppressant, Tacrolimus (FK 506)
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چکیده
منابع مشابه
Maculopathy Associated with Tacrolimus (FK 506)
A 63-year-old man with a history of liver transplantation presented to our clinic complaining of visual disturbance. He had been receiving tacrolimus (FK 506) for 30 months (6 mg/day for 2 years and 3 mg/day for 6 months); he reported that the visual disturbance began while taking tacrolimus. A full ophthalmologic examination and electrophysiologic and imaging studies were performed. The best c...
متن کاملFK-506, a novel immunosuppressant isolated from a Streptomyces. II. Immunosuppressive effect of FK-506 in vitro.
The immuno-pharmacological profile of a novel immunosuppressive agent, FK-506 produced by a streptomycete, is presented here. We proceeded to test the effect of the agent on various in vitro immune systems. It showed that mixed lymphocyte reaction, cytotoxic T cell generation, the production of T cell-derived soluble mediators such as interleukin 2 (IL-2), interleukin 3 and gamma-interferon and...
متن کاملIinfluence of the Immunosuppressant Tacrolimus (fk-506) on the Flexural Strength of Femur: a Study in Rats
OBJECTIVE To evaluate the resistance to femoral fractures among rats treated with the immunosuppressant tacrolimus FK-506 and compare these to untreated rats and rats treated with placebo. METHODS Ninety male Wistar rats were used. The animals were nine weeks old and weighed between 220 g and 280 g. The immunosuppressive agent tacrolimus was used in this study at a dose of 2 mg/kg/day, admini...
متن کاملFK 506: an effective immunosuppressant for islet xenotransplantation.
R EPLACING the damaged insulin-producing tissue by transplantation of pancreatic islets is considered the most physiological approach to diabetes treatment and has the potential to prevent the development of chronic complications. Due to the large number of potential diabetic recipients. it would be impossible to obtain sufficient supply of donor organs to fulfill the demands. One solution to r...
متن کاملTacrolimus ( FK 506 ) and the Pharmaceuticall Academid Regulatory Gauntlet
• The pivotal Issue of transplant rejection diagnosis and management Is design, conduct, and analysis of clinical trials. The historical experience with clinical trials of major immunosuppressive drugs (cyclosporine and especially tacrollmus) Is examined in this article. Cyclosporlne was a turning point In transplantation, providing an extraordinary Improvement over previous therapies. Addition...
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ژورنال
عنوان ژورنال: Nippon Nōgeikagaku Kaishi
سال: 1996
ISSN: 0002-1407,1883-6844
DOI: 10.1271/nogeikagaku1924.70.1